Evaluation of the Genotoxic and Antigenotoxic Effects of Andiroba (Carapa guianensis Aublet) Oil and Nanoemulsion on Swiss Mice
Joint Authors
Fascineli, Maria Luiza
Bentes de Azevedo, Ricardo
Milhomem-Paixão, Susana Suely Rodrigues
Muehlmann, Luis Alexandre
Melo, Karina Motta
Santos, Alberdan Silva
Grisolia, Cesar Koppe
Salgado, Hugo Leonardo Crisóstomo
Pieczarka, Julio Cesar
Nagamachi, Cleusa Yoshiko
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The Carapa guianensis (andiroba) oil is commonly used by the Amazon population for medicinal purposes.
The objective of this study was to determine the genotoxic and antigenotoxic potential of the andiroba oil (AO) and nanoemulsion (AN) using Swiss mice.
Therefore, we used the comet assay and micronucleus test.
The AO predominant compounds were oleic (39.13%), palmitic (33.22%), and linoleic (16.86%) acids.
AN composition obeyed the surfactant/oil ratio of 0.69, and the Tween 80/Span 80 ratio was held at 0.9.
Our results showed no cytotoxicity or genotoxicity in the mice treated with AO and AN alone.
However, there was a significant reduction in the polychromatic erythrocytes (PCEs) numbers in all groups treated with doxorubicin (DOX), including those pretreated with AO and AN.
Thus, the samples tested did not protect against DOX.
On the other hand, our results showed a large increase in micronucleus (MN) formation when the mice were treated with DOX alone; these numbers were reduced when the animals were pretreated with AO and AN.
The results indicate a protective effect of andiroba on MN formation and show no evidence of genotoxicity in mice.
American Psychological Association (APA)
Melo, Karina Motta& Fascineli, Maria Luiza& Milhomem-Paixão, Susana Suely Rodrigues& Grisolia, Cesar Koppe& Santos, Alberdan Silva& Salgado, Hugo Leonardo Crisóstomo…[et al.]. 2018. Evaluation of the Genotoxic and Antigenotoxic Effects of Andiroba (Carapa guianensis Aublet) Oil and Nanoemulsion on Swiss Mice. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1194160
Modern Language Association (MLA)
Melo, Karina Motta…[et al.]. Evaluation of the Genotoxic and Antigenotoxic Effects of Andiroba (Carapa guianensis Aublet) Oil and Nanoemulsion on Swiss Mice. Journal of Nanomaterials No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1194160
American Medical Association (AMA)
Melo, Karina Motta& Fascineli, Maria Luiza& Milhomem-Paixão, Susana Suely Rodrigues& Grisolia, Cesar Koppe& Santos, Alberdan Silva& Salgado, Hugo Leonardo Crisóstomo…[et al.]. Evaluation of the Genotoxic and Antigenotoxic Effects of Andiroba (Carapa guianensis Aublet) Oil and Nanoemulsion on Swiss Mice. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1194160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194160