Preparation and Drug Release Study of Novel Nanopharmaceuticals with Polysorbate 80 Surface Adsorption
Joint Authors
Zhu, Li
Feng, Xing
Yang, Xiao-Ping
Li, Yu
Tao, Xiao-Jun
Hu, Qian
Huang, Zixuan
Yi, Jiajin
Hu, Jianzhuo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Most free drugs that cross the blood–brain barrier are characterized by high liposolubility, but they often have limited clinical applications because of poor dissolution and poor bioavailability.
In this study, we prepared donepezil drug-loaded nanoparticles (DZP) with cholesterol-modified pullulan (CHP) as the nanocarrier (DZP-CHP) and surface modified the drug-loaded nanoparticles to improve the water solubility of donepezil while enhancing its targeting and sustained release.
We determined the drug loading and encapsulation efficiency of DZP-CHP nanoparticles at different feed ratios.
The mean ± SD drug loading and entrapment efficiency were high: 13.52 ± 2.03 and 86.54 ± 1.31.
On dynamic light-scattering measurement, mean ± SD particle size was 260.7 ± 1.76 nm, polydispersity index 0.123 ± 0.004, and zeta potential −5.75 ± 0.64 mV.
DZP-CHP nanoparticles prepared with the optimal feed ratio (DZP : CHP = 1 : 5) were coated with polysorbate 80, and the adsorption process was determined by isothermal titration calorimetry.
We found good affinity between polysorbate 80 and DZP-CHP, with mean ± SD coverage 2.7 ± 0.372.
The mean ± SD drug loading and entrapment efficiency of polysorbate 80-emulsified DZP-CHP nanoparticles were 8.25 ± 1.80 and 91.28 ± 4.57, respectively, and the proportion of drug released by 72 h was 42.71%.
Compared to DZP-CHP alone, PS-DZP-CHP can enhance the release of donepezil.
American Psychological Association (APA)
Tao, Xiao-Jun& Li, Yu& Hu, Qian& Zhu, Li& Huang, Zixuan& Yi, Jiajin…[et al.]. 2018. Preparation and Drug Release Study of Novel Nanopharmaceuticals with Polysorbate 80 Surface Adsorption. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1194163
Modern Language Association (MLA)
Tao, Xiao-Jun…[et al.]. Preparation and Drug Release Study of Novel Nanopharmaceuticals with Polysorbate 80 Surface Adsorption. Journal of Nanomaterials No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1194163
American Medical Association (AMA)
Tao, Xiao-Jun& Li, Yu& Hu, Qian& Zhu, Li& Huang, Zixuan& Yi, Jiajin…[et al.]. Preparation and Drug Release Study of Novel Nanopharmaceuticals with Polysorbate 80 Surface Adsorption. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1194163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194163