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Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases
Joint Authors
Cha, Sun Joo
Kim, Hayoung
Choi, Hyun-Jun
Lee, Sanghyun
Kim, Kiyoung
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Protein glutathionylation is a redox-mediated posttranslational modification that regulates the function of target proteins by conjugating glutathione with a cysteine thiol group on the target proteins.
Protein glutathionylation has several biological functions such as regulation of metabolic pathways, calcium homeostasis, signal transduction, remodeling of cytoskeleton, inflammation, and protein folding.
However, the exact role and mechanism of glutathionylation during irreversible oxidative stress has not been completely defined.
Irreversible oxidative damage is implicated in a number of neurological disorders.
Here, we discuss and highlight the most recent findings and several evidences for the association of glutathionylation with neurodegenerative diseases and the role of glutathionylation of specific proteins in the pathogenesis of neurodegenerative diseases.
Understanding the important role of glutathionylation in the pathogenesis of neurodegenerative diseases may provide insights into novel therapeutic interventions.
American Psychological Association (APA)
Cha, Sun Joo& Kim, Hayoung& Choi, Hyun-Jun& Lee, Sanghyun& Kim, Kiyoung. 2017. Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194171
Modern Language Association (MLA)
Cha, Sun Joo…[et al.]. Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1194171
American Medical Association (AMA)
Cha, Sun Joo& Kim, Hayoung& Choi, Hyun-Jun& Lee, Sanghyun& Kim, Kiyoung. Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194171