Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress
Joint Authors
Magnifico, Maria Chiara
Graziani, Manuela
Badiani, Aldo
Sarti, Paolo
Arese, Marzia
Saso, Luciano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Cocaine abuse has long been known to cause morbidity and mortality due to its cardiovascular toxic effects.
The pathogenesis of the cardiovascular toxicity of cocaine use has been largely reviewed, and the most recent data indicate a fundamental role of oxidative stress in cocaine-induced cardiovascular toxicity, indicating that mitochondrial dysfunction is involved in the mechanisms of oxidative stress.
The comprehension of the mechanisms involving mitochondrial dysfunction could help in selecting the most appropriate mitochondria injury biological marker, such as superoxide dismutase-2 activity and glutathionylated hemoglobin.
The potential use of modulators of oxidative stress (mitoubiquinone, the short-chain quinone idebenone, and allopurinol) in the treatment of cocaine cardiotoxic effects is also suggested to promote further investigations on these potential mitochondria-targeted antioxidant strategies.
American Psychological Association (APA)
Graziani, Manuela& Sarti, Paolo& Arese, Marzia& Magnifico, Maria Chiara& Badiani, Aldo& Saso, Luciano. 2017. Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194211
Modern Language Association (MLA)
Graziani, Manuela…[et al.]. Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194211
American Medical Association (AMA)
Graziani, Manuela& Sarti, Paolo& Arese, Marzia& Magnifico, Maria Chiara& Badiani, Aldo& Saso, Luciano. Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194211