Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance
Joint Authors
Skomro, Robert
Szahidewicz-Krupska, E.
Doroszko, A.
Jakubowski, Maciej
Derkacz, Arkadiusz
Dębski, J.
Turek-Jakubowska, A.
Gawryś, J.
Gawryś, K.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Thromboembolic events constitute a major health problem, despite the steadily expanding arsenal of antiplatelet drugs.
Hence, there is still a need to optimize the antiplatelet therapy.
Objectives.
The aim of our study was to verify a hypothesis that there are no differences in platelet proteome between two groups of healthy people representing different acetylsalicylic acid (aspirin) responses as assessed by the liquid chromatography/mass spectrometry (LC/MS) technique.
Patients/Methods.
A total of 61 healthy volunteers were recruited for the study.
Physical examination and blood collection were followed by platelet-rich plasma aggregation assays and platelet separation for proteomic LC/MS analysis.
Arachidonic acid- (AA-) induced aggregation (in the presence of aspirin) allowed to divide study participants into two groups aspirin-resistant (AR) and aspirin-sensitive (AS) ones.
Subsequently, platelet proteome was compared in groups using the LC/MS analysis.
Results.
The LC/MS analysis of platelet proteome between groups revealed that out of all identified proteins, the only discriminatory protein, affecting aspirin responsiveness, is platelet carbonic anhydrase II (CA II).
Conclusions.
CA II is a platelet function modulator and should be taken into consideration as a cardiovascular event risk factor or therapeutic target.
American Psychological Association (APA)
Jakubowski, Maciej& Dębski, J.& Szahidewicz-Krupska, E.& Turek-Jakubowska, A.& Gawryś, J.& Gawryś, K.…[et al.]. 2017. Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194244
Modern Language Association (MLA)
Jakubowski, Maciej…[et al.]. Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1194244
American Medical Association (AMA)
Jakubowski, Maciej& Dębski, J.& Szahidewicz-Krupska, E.& Turek-Jakubowska, A.& Gawryś, J.& Gawryś, K.…[et al.]. Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194244