In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents
Joint Authors
Liu, Shih-Jung
Ito, Hiroshi
Lin, Yi-Chia
Liu, Kuo-Sheng
Lee, Demei
Li, Min-Jhan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We develop novel analgesic-eluting nanofiber-incorporated ureteral stents that offer sustained release of lidocaine and ketorolac for local drug delivery.
Lidocaine and poly(D,L)-lactide-co-glycolide (PLGA) were dissolved in hexafluoroisopropanol and were electrospun into nonwoven nanofibers onto the surface of ureteral stents.
This was followed by electrospinning of another layer of PLGA nanofibers containing ketorolac.
Electrospun drug-loaded nanofibers were then characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and water contact angle analysis.
In addition, the elution behavior characteristics of the analgesics, both in vivo and in vitro, from the nanofiber-incorporated stents were evaluated.
Experimental results indicate that the analgesic-eluting ureteral stents could liberate high strengths of analgesics in vitro and in vivo for at least 50 and 30 days, respectively.
The analgesic-eluting nanofiber-incorporated ureteral stents are potentially applicable for alleviating the discomfort associated with stent implant.
American Psychological Association (APA)
Lin, Yi-Chia& Liu, Kuo-Sheng& Lee, Demei& Li, Min-Jhan& Liu, Shih-Jung& Ito, Hiroshi. 2018. In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1194253
Modern Language Association (MLA)
Lin, Yi-Chia…[et al.]. In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents. Journal of Nanomaterials No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1194253
American Medical Association (AMA)
Lin, Yi-Chia& Liu, Kuo-Sheng& Lee, Demei& Li, Min-Jhan& Liu, Shih-Jung& Ito, Hiroshi. In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1194253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194253