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Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
Joint Authors
Hood, David A.
Kim, Yuho
Triolo, Matthew
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Mitochondria are characterized by its pivotal roles in managing energy production, reactive oxygen species, and calcium, whose aging-related structural and functional deteriorations are observed in aging muscle.
Although it is still unclear how aging alters mitochondrial quality and quantity in skeletal muscle, dysregulation of mitochondrial biogenesis and dynamic controls has been suggested as key players for that.
In this paper, we summarize current understandings on how aging regulates muscle mitochondrial biogenesis, while focusing on transcriptional regulations including PGC-1α, AMPK, p53, mtDNA, and Tfam.
Further, we review current findings on the muscle mitochondrial dynamic systems in aging muscle: fusion/fission, autophagy/mitophagy, and protein import.
Next, we also discuss how endurance and resistance exercises impact on the mitochondrial quality controls in aging muscle, suggesting possible effective exercise strategies to improve/maintain mitochondrial health.
American Psychological Association (APA)
Kim, Yuho& Triolo, Matthew& Hood, David A.. 2017. Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194255
Modern Language Association (MLA)
Kim, Yuho…[et al.]. Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1194255
American Medical Association (AMA)
Kim, Yuho& Triolo, Matthew& Hood, David A.. Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194255