Sirtuins Expression and Their Role in Retinal Diseases
Joint Authors
Abu-Amero, Khaled K.
Kondkar, Altaf A.
Balaiya, Sankarathi
Chalam, Kakarla V.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sirtuins have received considerable attention since the discovery that silent information regulator 2 (Sir2) extends the lifespan of yeast.
Sir2, a nicotinamide adenine dinucleotide- (NAD-) dependent histone deacetylase, serves as both a transcriptional effector and energy sensor.
Oxidative stress and apoptosis are implicated in the pathogenesis of neurodegenerative eye diseases.
Sirtuins confer protection against oxidative stress and retinal degeneration.
In mammals, the sirtuin (SIRT) family consists of seven proteins (SIRT1–SIRT7).
These vary in tissue specificity, subcellular localization, and enzymatic activity and targets.
In this review, we present the current knowledge of the sirtuin family and discuss their structure, cellular location, and biological function with a primary focus on their role in different neuroophthalmic diseases including glaucoma, optic neuritis, and age-related macular degeneration.
The potential role of certain therapeutic targets is also described.
American Psychological Association (APA)
Balaiya, Sankarathi& Abu-Amero, Khaled K.& Kondkar, Altaf A.& Chalam, Kakarla V.. 2017. Sirtuins Expression and Their Role in Retinal Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194265
Modern Language Association (MLA)
Balaiya, Sankarathi…[et al.]. Sirtuins Expression and Their Role in Retinal Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1194265
American Medical Association (AMA)
Balaiya, Sankarathi& Abu-Amero, Khaled K.& Kondkar, Altaf A.& Chalam, Kakarla V.. Sirtuins Expression and Their Role in Retinal Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194265