Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation
Joint Authors
VanderVeen, Brandon N.
Fix, Dennis K.
Carson, James A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chronic inflammation is a hallmark of cancer cachexia in both patients and preclinical models.
Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20% of all cancer-related deaths.
Proinflammatory cytokines IL-6, TNF-α, and TGF-β have been widely examined for their regulation of cancer cachexia.
An established characteristic of cachectic skeletal muscle is a disrupted capacity for oxidative metabolism, which is thought to contribute to cancer patient fatigue, diminished metabolic function, and muscle mass loss.
This review’s primary objective is to highlight emerging evidence linking cancer-induced inflammation to the dysfunctional regulation of mitochondrial dynamics, mitophagy, and biogenesis in cachectic muscle.
The potential for either muscle inactivity or exercise to alter mitochondrial dysfunction during cancer cachexia will also be discussed.
American Psychological Association (APA)
VanderVeen, Brandon N.& Fix, Dennis K.& Carson, James A.. 2017. Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194308
Modern Language Association (MLA)
VanderVeen, Brandon N.…[et al.]. Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194308
American Medical Association (AMA)
VanderVeen, Brandon N.& Fix, Dennis K.& Carson, James A.. Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194308