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Evaluation of Serum-Paired miRNA Ratios for Early Diagnosis of Non-Small Cell Lung Cancer Using Quantum Dot-Based Suspension Array
Joint Authors
Chen, Hao
Fan, Lihong
Teng, Junliang
Li, Dan
Wang, Changhui
Xia, Qing
Qi, Huiwei
Su, Bo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Non-small cell lung cancer (NSCLC) lacks specific noninvasive markers at early stage.
Previous studies have indicated that several miRNAs may be potential noninvasive markers in the diagnosis of NSCLC.
In the present study, we examined the expression of 9 miRNAs in serum from 128 NSCLC patients at stage I and from 79 healthy controls using quantum dot-based suspension array.
Our results have demonstrated that the expression of miR-15b-5p and miR-17-5p was significantly increased in the serum of NSCLC cases, while the expression of miR-20a-5p, miR-16-5p, and miR-19a-3p were downregulated in NSCLC patients.
Receiver operating characteristic (ROC) curve analysis showed that the ratios of miR-15b-5p/miR-20a-5p and miR-15b-5p/miR-16-5p have the best performance for the diagnosis of early-stage NSCLC with a specificity of 83.2% and 79.2% and sensitivity of 74.3% and 86.8%, respectively.
The AUCs were 0.842 and 0.831.
In summary, miR-15b-5p/miR-20a-5p and miR-15b-5p/miR-16-5p ratios were both important indicators as well as CEA and CYFRA21-1 for the diagnosis of stage I NSCLC.
The ratios of miR-15b-5p/miR-20a-5p and miR-15b-5p/miR-16-5p could be used as novel noninvasive biomarkers for NSCLC diagnosis at early stage, particularly combined with serum CEA and CYFRA21-1 results.
American Psychological Association (APA)
Fan, Lihong& Chen, Hao& Teng, Junliang& Li, Dan& Wang, Changhui& Xia, Qing…[et al.]. 2018. Evaluation of Serum-Paired miRNA Ratios for Early Diagnosis of Non-Small Cell Lung Cancer Using Quantum Dot-Based Suspension Array. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1194359
Modern Language Association (MLA)
Fan, Lihong…[et al.]. Evaluation of Serum-Paired miRNA Ratios for Early Diagnosis of Non-Small Cell Lung Cancer Using Quantum Dot-Based Suspension Array. Journal of Nanomaterials No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1194359
American Medical Association (AMA)
Fan, Lihong& Chen, Hao& Teng, Junliang& Li, Dan& Wang, Changhui& Xia, Qing…[et al.]. Evaluation of Serum-Paired miRNA Ratios for Early Diagnosis of Non-Small Cell Lung Cancer Using Quantum Dot-Based Suspension Array. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1194359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194359