FOXO Transcriptional Factors and Long-Term Living
Joint Authors
Chen, Jianxin
Khan, Abida Kalsoom
Rashid, Rehana
Muneer, Saiqa
Hasan, Syed Muhammad Farid
Murtaza, Ghulam
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors.
Healthy aging conceives human longevity, possibly due to carrying the defensive genes.
For instance, FOXO (forkhead box O) genes determine human longevity.
FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling.
Only one FOXO gene (FOXO DAF-16) exists in invertebrates, while four FOXO genes, that is, FOXO1, FOXO3, FOXO4, and FOXO6 are found in mammals.
These four transcription factors are involved in the multiple cellular pathways, which regulate growth, stress resistance, metabolism, cellular differentiation, and apoptosis in mammals.
However, the accurate mode of longevity by FOXO factors is unclear until now.
This article describes briefly the existing knowledge that is related to the role of FOXO factors in human longevity.
American Psychological Association (APA)
Murtaza, Ghulam& Khan, Abida Kalsoom& Rashid, Rehana& Muneer, Saiqa& Hasan, Syed Muhammad Farid& Chen, Jianxin. 2017. FOXO Transcriptional Factors and Long-Term Living. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194365
Modern Language Association (MLA)
Murtaza, Ghulam…[et al.]. FOXO Transcriptional Factors and Long-Term Living. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1194365
American Medical Association (AMA)
Murtaza, Ghulam& Khan, Abida Kalsoom& Rashid, Rehana& Muneer, Saiqa& Hasan, Syed Muhammad Farid& Chen, Jianxin. FOXO Transcriptional Factors and Long-Term Living. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194365