Fe-S Clusters Emerging as Targets of Therapeutic Drugs
Joint Authors
Vernis, Laurence
El Banna, Nadine
Baïlle, Dorothée
Hatem, Elie
Heneman, Amélie
Huang, Meng-Er
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Fe-S centers exhibit strong electronic plasticity, which is of importance for insuring fine redox tuning of protein biological properties.
In accordance, Fe-S clusters are also highly sensitive to oxidation and can be very easily altered in vivo by different drugs, either directly or indirectly due to catabolic by-products, such as nitric oxide species (NOS) or reactive oxygen species (ROS).
In case of metal ions, Fe-S cluster alteration might be the result of metal liganding to the coordinating sulfur atoms, as suggested for copper.
Several drugs presented through this review are either capable of direct interaction with Fe-S clusters or of secondary Fe-S clusters alteration following ROS or NOS production.
Reactions leading to Fe-S cluster disruption are also reported.
Due to the recent interest and progress in Fe-S biology, it is very likely that an increasing number of drugs already used in clinics will emerge as molecules interfering with Fe-S centers in the near future.
Targeting Fe-S centers could also become a promising strategy for drug development.
American Psychological Association (APA)
Vernis, Laurence& El Banna, Nadine& Baïlle, Dorothée& Hatem, Elie& Heneman, Amélie& Huang, Meng-Er. 2017. Fe-S Clusters Emerging as Targets of Therapeutic Drugs. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194390
Modern Language Association (MLA)
Vernis, Laurence…[et al.]. Fe-S Clusters Emerging as Targets of Therapeutic Drugs. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194390
American Medical Association (AMA)
Vernis, Laurence& El Banna, Nadine& Baïlle, Dorothée& Hatem, Elie& Heneman, Amélie& Huang, Meng-Er. Fe-S Clusters Emerging as Targets of Therapeutic Drugs. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194390