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Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3KAkt Signaling and Limits Ventilator-Induced Lung Injury
Joint Authors
Spassov, Sashko Georgiev
Donus, Rosa
Ihle, Paul Mikael
Engelstaedter, Helen
Hoetzel, Alexander
Faller, Simone
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The development of ventilator-induced lung injury (VILI) is still a major problem in mechanically ventilated patients.
Low dose inhalation of hydrogen sulfide (H2S) during mechanical ventilation has been proven to prevent lung damage by limiting inflammatory responses in rodent models.
However, the capacity of H2S to affect oxidative processes in VILI and its underlying molecular signaling pathways remains elusive.
In the present study we show that ventilation with moderate tidal volumes of 12 ml/kg for 6 h led to an excessive formation of reactive oxygen species (ROS) in mice lungs which was prevented by supplemental inhalation of 80 parts per million of H2S.
In addition, phosphorylation of the signaling protein Akt was induced by H2S.
In contrast, inhibition of Akt by LY294002 during ventilation reestablished lung damage, neutrophil influx, and proinflammatory cytokine release despite the presence of H2S.
Moreover, the ability of H2S to induce the antioxidant glutathione and to prevent ROS production was reversed in the presence of the Akt inhibitor.
Here, we provide the first evidence that H2S-mediated Akt activation is a key step in protection against VILI, suggesting that Akt signaling limits not only inflammatory but also detrimental oxidative processes that promote the development of lung injury.
American Psychological Association (APA)
Spassov, Sashko Georgiev& Donus, Rosa& Ihle, Paul Mikael& Engelstaedter, Helen& Hoetzel, Alexander& Faller, Simone. 2017. Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3KAkt Signaling and Limits Ventilator-Induced Lung Injury. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194409
Modern Language Association (MLA)
Spassov, Sashko Georgiev…[et al.]. Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3KAkt Signaling and Limits Ventilator-Induced Lung Injury. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1194409
American Medical Association (AMA)
Spassov, Sashko Georgiev& Donus, Rosa& Ihle, Paul Mikael& Engelstaedter, Helen& Hoetzel, Alexander& Faller, Simone. Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3KAkt Signaling and Limits Ventilator-Induced Lung Injury. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194409