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Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats
Joint Authors
Uchida, Shunya
Shibata, Shigeru
Morimoto, Chikayuki
Asakawa, Shinichiro
Nakamura, Takashi
Shiraishi, Takeshi
Tamura, Yoshifuru
Kumagai, Takanori
Hosoyamada, Makoto
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear.
Accumulating studies also indicate that uric acid has both pro- and antioxidant properties.
We postulated that hyperuricemia impairs the function of glomerular podocytes, resulting in albuminuria.
Hyperuricemic model was induced by oral administration of 2% oxonic acid, a uricase inhibitor.
Oxonic acid caused a twofold increase in serum uric acid levels at 8 weeks when compared to control animals.
Hyperuricemia in this model was associated with the increase in blood pressure and the wall-thickening of afferent arterioles as well as arcuate arteries.
Notably, hyperuricemic rats showed significant albuminuria, and the podocyte injury marker, desmin, was upregulated in the glomeruli.
Conversely, podocin, the key component of podocyte slit diaphragm, was downregulated.
Structural analysis using transmission electron microscopy confirmed podocyte injury in this model.
We found that urinary 8-hydroxy-2′-deoxyguanosine levels were significantly increased and correlated with albuminuria and podocytopathy.
Interestingly, although the superoxide dismutase mimetic, tempol, ameliorated the vascular changes and the hypertension, it failed to reduce albuminuria, suggesting that vascular remodeling and podocyte injury in this model are mediated through different mechanisms.
In conclusion, vasculopathy and podocytopathy may distinctly contribute to the kidney injury in a hyperuricemic state.
American Psychological Association (APA)
Asakawa, Shinichiro& Shibata, Shigeru& Morimoto, Chikayuki& Shiraishi, Takeshi& Nakamura, Takashi& Tamura, Yoshifuru…[et al.]. 2017. Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194427
Modern Language Association (MLA)
Asakawa, Shinichiro…[et al.]. Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1194427
American Medical Association (AMA)
Asakawa, Shinichiro& Shibata, Shigeru& Morimoto, Chikayuki& Shiraishi, Takeshi& Nakamura, Takashi& Tamura, Yoshifuru…[et al.]. Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194427