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Oxidative Stress as a Physiological Pain Response in Full-Term Newborns
Joint Authors
Buonocore, Giuseppe
Longini, M.
Santacroce, A.
Proietti, F.
Picardi, A.
Tataranno, Maria Luisa
Bazzini, F.
Belvisi, Elisa
Bellieni, C. V.
Negro, S.
Iantorno, L.
Perrone, Serafina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This research paper aims to investigate if oxidative stress biomarkers increase after a painful procedure in term newborns and if nonpharmacological approaches, or sex, influence pain degree, and the subsequent OS.
83 healthy term newborns were enrolled to receive 10% oral glucose or sensorial saturation (SS) for analgesia during heel prick (HP).
The ABC scale was used to score the pain.
Advanced oxidation protein products (AOPP) and total hydroperoxides (TH) as biomarkers of OS were measured at the beginning (early-sample) and at the end (late-sample) of HP.
The early-sample/late-sample ratio for AOPP and TH was used to evaluate the increase in OS biomarkers after HP.
Higher levels of both AOPP and TH ratio were observed in high degree pain (4–6) compared with low degree pain score (0–3) (AOPP: p=0.049; TH: p=0.001).
Newborns receiving SS showed a significantly lower pain score (p=0.000) and AOPP ratio levels (p=0.021) than those without.
Males showed higher TH levels at the end of HP (p=0.005) compared to females.
The current study demonstrates that a relationship between pain degree and OS exists in healthy full-term newborns.
The amount of OS is gender related, being higher in males.
SS reduces pain score together with pain-related OS in the newborns.
American Psychological Association (APA)
Perrone, Serafina& Bellieni, C. V.& Negro, S.& Longini, M.& Santacroce, A.& Tataranno, Maria Luisa…[et al.]. 2017. Oxidative Stress as a Physiological Pain Response in Full-Term Newborns. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1194433
Modern Language Association (MLA)
Perrone, Serafina…[et al.]. Oxidative Stress as a Physiological Pain Response in Full-Term Newborns. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1194433
American Medical Association (AMA)
Perrone, Serafina& Bellieni, C. V.& Negro, S.& Longini, M.& Santacroce, A.& Tataranno, Maria Luisa…[et al.]. Oxidative Stress as a Physiological Pain Response in Full-Term Newborns. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1194433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194433