Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat
Joint Authors
Ye, Qi-Fa
Liu, Zhongzhong
Zhang, Xingjian
Xiao, Qi
Ye, Shaojun
Lai, Chin-Hui
Luo, Jun
Huang, Xiaoying
Wang, Wei
Zeng, Cheng
Zhong, Zibiao
Fan, Xiaoli
Xia, Zhiping
Xiong, Yan
Mao, Xinfang
Wang, Yanfeng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Severe hepatic ischemia reperfusion injury (IRI) can result in poor short- and long-term graft outcome after transplantation.
The way to improve the viability of livers from donors after circulatory death (DCD) is currently limited.
The aim of the present study was to explore the protective effect of simvastatin on DCD livers and investigate the underlying mechanism.
Methods.
24 male rats randomly received simvastatin or its vehicle.
30 min later, rat livers were exposed to warm ischemia in situ for 30 min.
Livers were removed and cold-stored in UW solution for 24 h, subsequently reperfused for 60 min with an isolated perfused rat liver system.
Liver injury was evaluated during and after warm reperfusion.
Results.
Pretreatment of DCD donors with simvastatin significantly decreased IRI liver enzyme release, increased bile output and ATP, and ameliorated hepatic pathological changes.
Simvastatin maintained the expression of KLF2 and its protective target genes (eNOS, TM, and HO-1), reduced oxidative stress, inhibited innate immune responses and inflammation, and increased the expression of Bcl-2/Bax to suppress hepatocyte apoptosis compared to DCD control group.
Conclusion.
Pretreatment of DCD donors with simvastatin improves DCD livers’ functional recovery probably through a KLF2-dependent mechanism.
These data suggest that simvastatin may provide a potential benefit for clinical DCD liver transplantation.
American Psychological Association (APA)
Liu, Zhongzhong& Zhang, Xingjian& Xiao, Qi& Ye, Shaojun& Lai, Chin-Hui& Luo, Jun…[et al.]. 2017. Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194460
Modern Language Association (MLA)
Liu, Zhongzhong…[et al.]. Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1194460
American Medical Association (AMA)
Liu, Zhongzhong& Zhang, Xingjian& Xiao, Qi& Ye, Shaojun& Lai, Chin-Hui& Luo, Jun…[et al.]. Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194460