![](/images/graphics-bg.png)
A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling
Joint Authors
De Falco, Elena
Chimenti, Isotta
Angelini, Francesco
Nocella, Cristina
Sciarretta, Sebastiano
Frati, G.
Bordin, Antonella
Vecchione, Carmine
Forte, Maurizio
Carrizzo, Albino
Schirone, Leonardo
Palmerio, Silvia
Pagano, Francesca
Valenti, Valentina
Yee, Derek
Schiavon, Sonia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-02
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Among the complex signaling network that characterizes myocardial remodeling, the distinct processes are myocyte loss, cardiac hypertrophy, alteration of extracellular matrix homeostasis, fibrosis, defective autophagy, metabolic abnormalities, and mitochondrial dysfunction.
Several pathophysiological stimuli, such as pressure and volume overload, trigger the remodeling cascade, a process that initially confers protection to the heart as a compensatory mechanism.
Yet chronic inflammation after myocardial infarction also leads to cardiac remodeling that, when prolonged, leads to heart failure progression.
Here, we review the molecular pathways involved in cardiac remodeling, with particular emphasis on those associated with myocardial infarction.
A better understanding of cell signaling involved in cardiac remodeling may support the development of new therapeutic strategies towards the treatment of heart failure and reduction of cardiac complications.
We will also discuss data derived from gene therapy approaches for modulating key mediators of cardiac remodeling.
American Psychological Association (APA)
Schirone, Leonardo& Forte, Maurizio& Palmerio, Silvia& Yee, Derek& Nocella, Cristina& Angelini, Francesco…[et al.]. 2017. A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194481
Modern Language Association (MLA)
Schirone, Leonardo…[et al.]. A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1194481
American Medical Association (AMA)
Schirone, Leonardo& Forte, Maurizio& Palmerio, Silvia& Yee, Derek& Nocella, Cristina& Angelini, Francesco…[et al.]. A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194481