Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification
Joint Authors
Sandeman, S. R.
Zheng, Yishan
Pescatore, Nicholas
Gogotsi, Yury
Dyatkin, Boris
Ingavle, Ganesh
Mochalin, Vadym
Ozulumba, Tochukwu
Mikhalovsky, Sergey V.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sepsis is a complex clinical syndrome that features excessive release of cytokines and other inflammatory mediators that could lead to organ dysfunction.
Despite different treatment and management options, sepsis associated high morbidity and mortality rates remain.
This has prompted intensive research into alternative therapeutic approaches such as targeted removal of sepsis related molecules using extracorporeal hemoperfusion.
In this study, we explore the use of graphene nanoplatelets (GNP) as low-cost alternative hemosorbents for rapid removal of a broad spectrum of proinflammatory cytokine markers.
Firstly, the physical characteristics, cytotoxicity, and cytokine marker adsorption profile of GNP were assessed.
The results not only confirmed the surface characteristics of GNP and their ability to rapidly remove cytokine markers, but also indicated a low cytotoxicity towards the hepatic cell line HepG2.
GNP were then incorporated into a freestanding flexible GNP-poly(tetrafluoroethylene) film with preserved surface characteristics and cytokine adsorption profile for potential use in hemoperfusion applications.
American Psychological Association (APA)
Zheng, Yishan& Pescatore, Nicholas& Gogotsi, Yury& Dyatkin, Boris& Ingavle, Ganesh& Mochalin, Vadym…[et al.]. 2018. Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1194515
Modern Language Association (MLA)
Zheng, Yishan…[et al.]. Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification. Journal of Nanomaterials No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1194515
American Medical Association (AMA)
Zheng, Yishan& Pescatore, Nicholas& Gogotsi, Yury& Dyatkin, Boris& Ingavle, Ganesh& Mochalin, Vadym…[et al.]. Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1194515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194515