Dihydropyridine Derivatives as Cell Growth Modulators In Vitro
Joint Authors
Velena, Astrida
Zarkovic, Neven
Bisenieks, Egils
Poikans, Janis
Bruvere, Imanta
Uldrikis, Janis
Plotniece, Aiva
Pajuste, Karlis
Rucins, Martins
Vigante, Brigita
Kalme, Zenta
Gosteva, Marina
Domracheva, Ilona
Vukovic, Tea
Milkovic, Lidija
Duburs, Gunars
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The effects of eleven 1,4-dihydropyridine derivatives (DHPs) used alone or together with prooxidant anticancer drug doxorubicin were examined on two cancer (HOS, HeLa) and two nonmalignant cell lines (HMEC, L929).
Their effects on the cell growth (3H-thymidine incorporation) were compared with their antiradical activities (DPPH assay), using well-known DHP antioxidant diludine as a reference.
Thus, tested DHPs belong to three groups: (1) antioxidant diludine; (2) derivatives with pyridinium moieties at position 4 of the 1,4-DHP ring; (3) DHPs containing cationic methylene onium (pyridinium, trialkylammonium) moieties at positions 2 and 6 of the 1,4-DHP ring.
Diludine and DHPs of group 3 exerted antiradical activities, unlike compounds of group 2.
However, novel DHPs had cell type and concentration dependent effects on 3H-thymidine incorporation, while diludine did not.
Hence, IB-32 (group 2) suppressed the growth of HOS and HeLa, enhancing growth of L929 cells, while K-2-11 (group 3) enhanced growth of every cell line tested, even in the presence of doxorubicin.
Therefore, growth regulating and antiradical activity principles of novel DHPs should be further studied to find if DHPs of group 2 could selectively suppress cancer growth and if those of group 3 promote wound healing.
American Psychological Association (APA)
Bruvere, Imanta& Bisenieks, Egils& Poikans, Janis& Uldrikis, Janis& Plotniece, Aiva& Pajuste, Karlis…[et al.]. 2017. Dihydropyridine Derivatives as Cell Growth Modulators In Vitro. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194535
Modern Language Association (MLA)
Bruvere, Imanta…[et al.]. Dihydropyridine Derivatives as Cell Growth Modulators In Vitro. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194535
American Medical Association (AMA)
Bruvere, Imanta& Bisenieks, Egils& Poikans, Janis& Uldrikis, Janis& Plotniece, Aiva& Pajuste, Karlis…[et al.]. Dihydropyridine Derivatives as Cell Growth Modulators In Vitro. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194535