Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children
Joint Authors
Deli, Chariklia K.
Jamurtas, Athanasios Z.
Zalavras, Athanasios
Fatouros, Ioannis G.
Tsiokanos, Athanasios
Georgakouli, Kalliopi
Avloniti, Alexandra
Koutedakis, Yiannis
Paschalis, Vassilis
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress.
We examined if iron supplementation would alter redox status after eccentric exercise.
In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n=14) and children (n=11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout.
Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status.
Iron supplementation at rest increased iron concentration and transferrin saturation (p<0.01).
In adults, CK activity increased at 72 h after exercise, while no changes occurred in children.
Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition.
Eccentric exercise decreased bilirubin concentration at 72 h in all groups.
Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children.
This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis.
This study was registered at Clinicaltrials.gov Identifier: NCT02374619.
American Psychological Association (APA)
Deli, Chariklia K.& Fatouros, Ioannis G.& Paschalis, Vassilis& Tsiokanos, Athanasios& Georgakouli, Kalliopi& Zalavras, Athanasios…[et al.]. 2017. Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194568
Modern Language Association (MLA)
Deli, Chariklia K.…[et al.]. Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194568
American Medical Association (AMA)
Deli, Chariklia K.& Fatouros, Ioannis G.& Paschalis, Vassilis& Tsiokanos, Athanasios& Georgakouli, Kalliopi& Zalavras, Athanasios…[et al.]. Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194568