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Amifostine Pretreatment Attenuates Myocardial IschemiaReperfusion Injury by Inhibiting Apoptosis and Oxidative Stress
Joint Authors
Xue, Yang-jing
Wang, Jie
Ji, Kangting
Wu, Shao-ze
Tao, Lu-yuan
Wang, Jiao-ni
Xu, Zhi-qiang
Huang, Kai-yu
Lin, Jia-feng
Li, Lei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study was aimed at investigating the effect of amifostine on myocardial ischemia/reperfusion (I/R) injury of mice and H9c2 cells cultured with TBHP (tert-butyl hydroperoxide).
The results showed that pretreatment with amifostine significantly attenuated cell apoptosis and death, accompanied by decreased reactive oxygen species (ROS) production and lower mitochondrial potential (ΔΨm).
In vivo, amifostine pretreatment alleviated I/R injury and decreased myocardial apoptosis and infarct area, which was paralleled by increased superoxide dismutase (SOD) and reduced malondialdehyde (MDA) in myocardial tissues, increased Bcl2 expression, decreased Bax expression, lower cleaved caspase-3 level, fewer TUNEL positive cells, and fewer DHE-positive cells in heart.
Our results indicate that amifostine pretreatment has a protective effect against myocardial I/R injury via scavenging ROS.
American Psychological Association (APA)
Wu, Shao-ze& Tao, Lu-yuan& Wang, Jiao-ni& Xu, Zhi-qiang& Wang, Jie& Xue, Yang-jing…[et al.]. 2017. Amifostine Pretreatment Attenuates Myocardial IschemiaReperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194594
Modern Language Association (MLA)
Wu, Shao-ze…[et al.]. Amifostine Pretreatment Attenuates Myocardial IschemiaReperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194594
American Medical Association (AMA)
Wu, Shao-ze& Tao, Lu-yuan& Wang, Jiao-ni& Xu, Zhi-qiang& Wang, Jie& Xue, Yang-jing…[et al.]. Amifostine Pretreatment Attenuates Myocardial IschemiaReperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194594