Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats
Joint Authors
Duan, Qi
Wang, Tingting
Yao, Xiaomei
Lin, Laixiang
Liang, Xue
Abeysekera, Iruni Roshanie
Iqbal, Umar
Naha, Gargi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Wistar rats were randomly divided into groups of varying iodide intake: normal iodide; 10 times high iodide; and 100 times high iodide on Days 7, 14, and 28.
Insignificant changes were observed in thyroid hormone levels (p>0.05).
Urinary iodine concentration and iodine content in the thyroid glands increased after high consumption of iodide from NI to 100 HI (p<0.05).
The urinary iodine concentration of the 100 HI group on Days 7, 14, and 28 was 60–80 times that of the NI group.
The mitochondrial superoxide production and expressions of Nrf2, Srx, and Prx 3 all significantly increased, while Keap 1 significantly decreased in the 100 HI group when compared to the NI or 10 HI group on Days 7, 14, and 28 (p<0.05).
Immunofluorescence staining results showed that Nrf2 was localized in the cytoplasm in NI group.
Although Nrf2 was detected in both cytoplasm and nucleus in 10 HI and 100 HI groups, a stronger positive staining was found in the nucleus.
We conclude that the activation of the Nrf2-Keap 1 antioxidative defense mechanism may play a crucial role in protecting thyroid function from short-term iodide excess in rats.
American Psychological Association (APA)
Wang, Tingting& Liang, Xue& Abeysekera, Iruni Roshanie& Iqbal, Umar& Duan, Qi& Naha, Gargi…[et al.]. 2017. Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194702
Modern Language Association (MLA)
Wang, Tingting…[et al.]. Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194702
American Medical Association (AMA)
Wang, Tingting& Liang, Xue& Abeysekera, Iruni Roshanie& Iqbal, Umar& Duan, Qi& Naha, Gargi…[et al.]. Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194702