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Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies
Joint Authors
Wang, Zi-Ling
Tian, Tian
Zhang, Jinhua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-28
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has risen worldwide in recent years.
Accumulating evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of IBD.
This review highlights the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms in the gastrointestinal (GI) tract, the involvement of oxidative stress signaling in the initiation and progression of IBD and its relationships with genetic susceptibility and the mucosal immune response.
In addition, potential therapeutic strategies for IBD that target oxidative stress signaling are reviewed and discussed.
Though substantial progress has been made in understanding the role of oxidative stress in IBD in humans and experimental animals, the underlying mechanisms are still not well defined.
Thus, further studies are needed to validate how oxidative stress signaling is involved in and contributes to the development of IBD.
American Psychological Association (APA)
Tian, Tian& Wang, Zi-Ling& Zhang, Jinhua. 2017. Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194739
Modern Language Association (MLA)
Tian, Tian…[et al.]. Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1194739
American Medical Association (AMA)
Tian, Tian& Wang, Zi-Ling& Zhang, Jinhua. Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194739