Oxidative Stress Modulation and ROS-Mediated Toxicity in Cancer: A Review on In Vitro Models for Plant-Derived Compounds
Joint Authors
Grijalva, Marcelo
Vallejo, María José
Salazar, Lizeth
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Medicinal and aromatic plants (MAPs) are known and have been long in use for a variety of health and cosmetics applications.
Potential pharmacological usages that take advantage of bioactive plant-derived compounds’ antimicrobial, antifungal, anti-inflammatory, and antioxidant properties are being developed and many new ones explored.
Some phytochemicals could trigger ROS-mediated cytotoxicity and apoptosis in cancer cells.
A lot of effort has been put into investigating novel active constituents for cancer therapeutics.
While other plant-derived compounds might enhance antioxidant defenses by either radical scavenging or stimulation of intracellular antioxidant enzymes, the generation of reactive oxygen species (ROS) leading to oxidative stress is one of the strategies that may show effective in damaging cancer cells.
The biochemical pathways involved in plant-derived bioactive compounds’ properties are complex, and in vitro platforms have been useful for a comprehensive understanding of the mechanism of action of these potential anticancer drugs.
The present review aims at compiling the findings of particularly interesting studies that use cancer cell line models for assessment of antioxidant and oxidative stress modulation properties of plant-derived bioactive compounds.
American Psychological Association (APA)
Vallejo, María José& Salazar, Lizeth& Grijalva, Marcelo. 2017. Oxidative Stress Modulation and ROS-Mediated Toxicity in Cancer: A Review on In Vitro Models for Plant-Derived Compounds. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194746
Modern Language Association (MLA)
Vallejo, María José…[et al.]. Oxidative Stress Modulation and ROS-Mediated Toxicity in Cancer: A Review on In Vitro Models for Plant-Derived Compounds. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1194746
American Medical Association (AMA)
Vallejo, María José& Salazar, Lizeth& Grijalva, Marcelo. Oxidative Stress Modulation and ROS-Mediated Toxicity in Cancer: A Review on In Vitro Models for Plant-Derived Compounds. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194746