Controlled Release of Ursodeoxycholic Acid from Pullulan Acetate Nanoparticles to Modulate Glutamate-Induced Excitotoxicity in PC-12 Cells
Joint Authors
Kang, Seong Hee
Kim, Do Kyung
Gil Jeong, Young
Yu, Kwang Sik
Oh, Jun Young
Kim, Min Cheol
Lee, Nam Seob
Han, Seung-Yun
Ryu, Ki Hyun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The neuroprotective effects of the ursodeoxycholic acid- (UDCA-) loaded pullulan acetate (PA) (UDCA-PA) nanospheres stabilized by poly(vinyl alcohol) (PVA) were identified by in vitro study.
The UDCA-PA nanospheres were constructed by nanoemulsion process.
The UDCA-PA nanospheres were analyzed using Fourier transform-infrared spectroscopy (FT-IR) and transmission electron microscopy (TEM).
Then, the UDCA-PA nanospheres were used to treat PC-12 neuronal cells, which were formerly triggered by glutamate-induced excitotoxicity.
As a result, the cells treated with the UDCA-PA nanospheres showed higher survival rate against glutamate-induced excitotoxicity.
Furthermore, the UDCA-PA nanospheres decreased immunoreactivity of Annexin V, a membrane marker for apoptotic cells, in PC-12 with glutamate-induced injury.
Particularly, the UDCA-PA nanospheres decreased the level of apoptosis-related proteins such as caspase-3.
Taken together, the UDCA-PA nanospheres increased neuroprotective effects against glutamate-induced neuronal damage via inhibition of apoptosis at low concentration.
American Psychological Association (APA)
Yu, Kwang Sik& Oh, Jun Young& Kim, Min Cheol& Kang, Seong Hee& Lee, Nam Seob& Han, Seung-Yun…[et al.]. 2018. Controlled Release of Ursodeoxycholic Acid from Pullulan Acetate Nanoparticles to Modulate Glutamate-Induced Excitotoxicity in PC-12 Cells. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1194754
Modern Language Association (MLA)
Yu, Kwang Sik…[et al.]. Controlled Release of Ursodeoxycholic Acid from Pullulan Acetate Nanoparticles to Modulate Glutamate-Induced Excitotoxicity in PC-12 Cells. Journal of Nanomaterials No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1194754
American Medical Association (AMA)
Yu, Kwang Sik& Oh, Jun Young& Kim, Min Cheol& Kang, Seong Hee& Lee, Nam Seob& Han, Seung-Yun…[et al.]. Controlled Release of Ursodeoxycholic Acid from Pullulan Acetate Nanoparticles to Modulate Glutamate-Induced Excitotoxicity in PC-12 Cells. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1194754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194754