SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice
Joint Authors
Ma, Sai
Han, Dong
Chen, Jiangwei
Li, Congye
Fan, Miaomiao
Cao, Feng
Zhang, Ran
Feng, Jing
Yang, Bo
Wang, Yabin
Li, Xiang
Tian, Zuhong
Li, Xiujuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Diabetic cardiomyopathy (DCM) is a major threat for diabetic patients.
Silent information regulator 1 (SIRT1) has a regulatory effect on mitochondrial dynamics, which is associated with DCM pathological changes.
Our study aims to investigate whether resveratrol, a SRIT1 activator, could exert a protective effect against DCM.
Methods and Results.
Cardiac-specific SIRT1 knockout (SIRT1KO) mice were generated using Cre-loxP system.
SIRT1KO mice displayed symptoms of DCM, including cardiac hypertrophy and dysfunction, insulin resistance, and abnormal glucose metabolism.
DCM and SIRT1KO hearts showed impaired mitochondrial biogenesis and function, while SIRT1 activation by resveratrol reversed this in DCM mice.
High glucose caused increased apoptosis, impaired mitochondrial biogenesis, and function in cardiomyocytes, which was alleviated by resveratrol.
SIRT1 deletion by both SIRT1KO and shRNA abolished the beneficial effects of resveratrol.
Furthermore, the function of SIRT1 is mediated via the deacetylation effect on peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), thus inducing increased expression of nuclear respiratory factor 1 (NRF-1), NRF-2, estrogen-related receptor-α (ERR-α), and mitochondrial transcription factor A (TFAM).
Conclusions.
Cardiac deletion of SIRT1 caused phenotypes resembling DCM.
Activation of SIRT1 by resveratrol ameliorated cardiac injuries in DCM through PGC-1α-mediated mitochondrial regulation.
Collectively, SIRT1 may serve as a potential therapeutic target for DCM.
American Psychological Association (APA)
Ma, Sai& Feng, Jing& Zhang, Ran& Chen, Jiangwei& Han, Dong& Li, Xiang…[et al.]. 2017. SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194757
Modern Language Association (MLA)
Ma, Sai…[et al.]. SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194757
American Medical Association (AMA)
Ma, Sai& Feng, Jing& Zhang, Ran& Chen, Jiangwei& Han, Dong& Li, Xiang…[et al.]. SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194757