Altering the Biodegradation of Mesoporous Silica Nanoparticles by Means of Experimental Parameters and Surface Functionalization
Joint Authors
Seo, Jin W.
Seré, Stephanie
De Roo, Bert
Vervaele, Mattias
Van Gool, Stefaan
Jacobs, Sandra
Locquet, Jean-Pierre
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mesoporous silica nanoparticles (MSNPs) are gaining a large interest in the field of medical and biomedical applications due to their biodegradability and high loading capacity as a carrier.
In this work, a simple synthesis and functionalization procedure is reported, which allows tuning the nanoparticle properties, functionalization, and biodegradability.
Variations in the synthesis procedure are introduced, including temperature, concentration of catalyst, and surface functionalization.
These samples are characterized and afterwards degraded in phosphate buffered saline (PBS) to determine their degradation kinetics.
The amount of degraded material is colorimetrically determined, using an optimized protocol based on molybdenum blue chemistry.
It is shown that the degradability of the nanoparticles increased with decreasing synthesis temperatures, lower amounts of catalyst, and higher concentrations of nanoparticles.
Surface functionalization alters the degradation kinetics as well, rendering amino-functionalized nanoparticles the fastest degradation behavior, followed by carboxylated and nonfunctionalized nanoparticles.
From these results, it can be concluded that the degradation rate of MSNPs can be varied from a few hours to several days by small changes in the synthesis procedure.
Moreover, the degradation behavior is strongly dependent on the nanoparticle growth rate.
American Psychological Association (APA)
Seré, Stephanie& De Roo, Bert& Vervaele, Mattias& Van Gool, Stefaan& Jacobs, Sandra& Seo, Jin W.…[et al.]. 2018. Altering the Biodegradation of Mesoporous Silica Nanoparticles by Means of Experimental Parameters and Surface Functionalization. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1194769
Modern Language Association (MLA)
Seré, Stephanie…[et al.]. Altering the Biodegradation of Mesoporous Silica Nanoparticles by Means of Experimental Parameters and Surface Functionalization. Journal of Nanomaterials No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1194769
American Medical Association (AMA)
Seré, Stephanie& De Roo, Bert& Vervaele, Mattias& Van Gool, Stefaan& Jacobs, Sandra& Seo, Jin W.…[et al.]. Altering the Biodegradation of Mesoporous Silica Nanoparticles by Means of Experimental Parameters and Surface Functionalization. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1194769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194769