![](/images/graphics-bg.png)
Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis
Joint Authors
Vásquez-Garzón, Verónica R.
Villa-Treviño, Saúl
Carrasco-Torres, Gabriela
Baltiérrez-Hoyos, Rafael
Monroy-Ramírez, Hugo Christian
Martínez-Guerra, Arturo Axayacatl
Romero-Tlalolini, María de los Ángeles
Sánchez-Chino, Xariss
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Quercetin is a flavonoid widely studied as a chemopreventive agent in different types of cancer.
Previously, we reported that quercetin has a chemopreventive effect on the liver-induced preneoplastic lesions in rats.
Here, we evaluated if quercetin was able not only to prevent but also to reverse rat liver preneoplastic lesions.
We used the modified resistant hepatocyte model (MRHM) to evaluate this possibility.
Treatment with quercetin was used 15 days after the induction of preneoplastic lesions.
We found that quercetin reverses the number of preneoplastic lesions and their areas.
Our results showed that quercetin downregulates the expression of EGFR and modulates this signaling pathway in spite of the activated status of EGFR as detected by the upregulation of this receptor, with respect to that observed in control rats.
Besides, quercetin affects the phosphorylation status of Src-1, STAT5, and Sp-1.
The better status of the liver after the treatment with quercetin could also be confirmed by the recovery in the expression of IGF-1.
In conclusion, we suggest that quercetin reversed preneoplastic lesions by EGFR modulation and the activation state of Src, STAT5, and Sp1, so as the basal IGF-1.
American Psychological Association (APA)
Carrasco-Torres, Gabriela& Monroy-Ramírez, Hugo Christian& Martínez-Guerra, Arturo Axayacatl& Baltiérrez-Hoyos, Rafael& Romero-Tlalolini, María de los Ángeles& Villa-Treviño, Saúl…[et al.]. 2017. Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194774
Modern Language Association (MLA)
Carrasco-Torres, Gabriela…[et al.]. Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1194774
American Medical Association (AMA)
Carrasco-Torres, Gabriela& Monroy-Ramírez, Hugo Christian& Martínez-Guerra, Arturo Axayacatl& Baltiérrez-Hoyos, Rafael& Romero-Tlalolini, María de los Ángeles& Villa-Treviño, Saúl…[et al.]. Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194774