A Review of mTOR Pathway Inhibitors in Gynecologic Cancer
Joint Authors
de Melo, Andréia Cristina
Paulino, Eduardo
Garces, Álvaro Henrique Ingles
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The treatment of advanced gynecologic cancers remains palliative in most of cases.
Although systemic treatment has entered into the era of targeted drugs the antitumor efficacies of current therapies are still limited.
In this context there is a great need for more active treatment and rationally designed targeted therapies.
The PI3K/AKT/mTOR is a signaling pathway in mammal cells that coordinates important cell activities.
It has a critical function in the survival, growth, and proliferation of malignant cells and was object of important research in the last two decades.
The mTOR pathway emerges as an attractive therapeutic target in cancer because it serves as a convergence point for many growth stimuli and, through its downstream substrates, controls cellular processes that contribute to the initiation and maintenance of cancer.
Aberrant PI3K-dependent signaling occurs frequently in a wide range of tumor types, including endometrial, cervical, and ovarian cancers.
The present study reviewed the available evidence regarding the potential impact of some mTOR pathway inhibitors in the treatment of gynecological cancer.
Few advances in medical management have occurred in recent years in the treatment of advanced or recurrent gynecological malignancies, and a poor prognosis remains.
Rationally designed molecularly targeted therapy is an emerging and important option in this setting; then more investigation in PI3K/AKT/mTOR pathway-targeted therapies is warranted.
American Psychological Association (APA)
de Melo, Andréia Cristina& Paulino, Eduardo& Garces, Álvaro Henrique Ingles. 2017. A Review of mTOR Pathway Inhibitors in Gynecologic Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194809
Modern Language Association (MLA)
de Melo, Andréia Cristina…[et al.]. A Review of mTOR Pathway Inhibitors in Gynecologic Cancer. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1194809
American Medical Association (AMA)
de Melo, Andréia Cristina& Paulino, Eduardo& Garces, Álvaro Henrique Ingles. A Review of mTOR Pathway Inhibitors in Gynecologic Cancer. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194809