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Targeting Endothelial Function to Treat Heart Failure with Preserved Ejection Fraction: The Promise of Exercise Training
Joint Authors
Van Craenenbroeck, Emeline M.
Vrints, Christiaan J.
Gevaert, Andreas B.
Lemmens, Katrien
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-19
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Although the burden of heart failure with preserved ejection fraction (HFpEF) is increasing, there is no therapy available that improves prognosis.
Clinical trials using beta blockers and angiotensin converting enzyme inhibitors, cardiac-targeting drugs that reduce mortality in heart failure with reduced ejection fraction (HFrEF), have had disappointing results in HFpEF patients.
A new “whole-systems” approach has been proposed for designing future HFpEF therapies, moving focus from the cardiomyocyte to the endothelium.
Indeed, dysfunction of endothelial cells throughout the entire cardiovascular system is suggested as a central mechanism in HFpEF pathophysiology.
The objective of this review is to provide an overview of current knowledge regarding endothelial dysfunction in HFpEF.
We discuss the molecular and cellular mechanisms leading to endothelial dysfunction and the extent, presence, and prognostic importance of clinical endothelial dysfunction in different vascular beds.
We also consider implications towards exercise training, a promising therapy targeting system-wide endothelial dysfunction in HFpEF.
American Psychological Association (APA)
Gevaert, Andreas B.& Lemmens, Katrien& Vrints, Christiaan J.& Van Craenenbroeck, Emeline M.. 2017. Targeting Endothelial Function to Treat Heart Failure with Preserved Ejection Fraction: The Promise of Exercise Training. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1194819
Modern Language Association (MLA)
Gevaert, Andreas B.…[et al.]. Targeting Endothelial Function to Treat Heart Failure with Preserved Ejection Fraction: The Promise of Exercise Training. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1194819
American Medical Association (AMA)
Gevaert, Andreas B.& Lemmens, Katrien& Vrints, Christiaan J.& Van Craenenbroeck, Emeline M.. Targeting Endothelial Function to Treat Heart Failure with Preserved Ejection Fraction: The Promise of Exercise Training. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1194819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194819