Omega Class Glutathione S-Transferase: Antioxidant Enzyme in Pathogenesis of Neurodegenerative Diseases
Joint Authors
Cha, Sun Joo
Choi, Hyun-Jun
Kim, Kiyoung
Kim, Youngjo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The omega class glutathione S-transferases (GSTOs) are multifunctional enzymes involved in cellular defense and have distinct structural and functional characteristics, which differ from those of other GSTs.
Previous studies provided evidence for the neuroprotective effects of GSTOs.
However, the molecular mechanisms underpinning the neuroprotective functions of GSTOs have not been fully elucidated.
Recently, our genetic and molecular studies using the Drosophila system have suggested that GstO1 has a protective function against H2O2-induced neurotoxicity by regulating the MAPK signaling pathway, and GstO2 is required for the activation of mitochondrial ATP synthase in the Drosophila neurodegenerative disease model.
The comprehensive understanding of various neuroprotection mechanisms of Drosophila GstOs from our studies provides valuable insight into the neuroprotective functions of GstOs in vivo.
In this review, we briefly introduce recent studies and summarize the novel biological functions and mechanisms underpinning neuroprotective effects of GstOs in Drosophila.
American Psychological Association (APA)
Kim, Youngjo& Cha, Sun Joo& Choi, Hyun-Jun& Kim, Kiyoung. 2017. Omega Class Glutathione S-Transferase: Antioxidant Enzyme in Pathogenesis of Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1194846
Modern Language Association (MLA)
Kim, Youngjo…[et al.]. Omega Class Glutathione S-Transferase: Antioxidant Enzyme in Pathogenesis of Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1194846
American Medical Association (AMA)
Kim, Youngjo& Cha, Sun Joo& Choi, Hyun-Jun& Kim, Kiyoung. Omega Class Glutathione S-Transferase: Antioxidant Enzyme in Pathogenesis of Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1194846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194846