Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage
Joint Authors
Hopkinson, Branden M.
Kalisz, Mark
Vestentoft, Peter Siig
Bisgaard, Hanne Cathrine
Desler, Claus
Juel Rasmussen, Lene
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells.
Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking.
Here we show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage.
Our study reveals especially the transition between hepatic specification and hepatic maturation as dependent on mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation.
American Psychological Association (APA)
Hopkinson, Branden M.& Desler, Claus& Kalisz, Mark& Vestentoft, Peter Siig& Juel Rasmussen, Lene& Bisgaard, Hanne Cathrine. 2017. Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194857
Modern Language Association (MLA)
Hopkinson, Branden M.…[et al.]. Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1194857
American Medical Association (AMA)
Hopkinson, Branden M.& Desler, Claus& Kalisz, Mark& Vestentoft, Peter Siig& Juel Rasmussen, Lene& Bisgaard, Hanne Cathrine. Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194857