BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage
Joint Authors
Lu, Jia-Hong
Tan, Jieqiong
Qin, Li-xia
Zhang, Hai-nan
Rizwana, Kousar
Tang, Jian-guang
Jiang, Bo
Shen, Xiang-min
Guo, Ji-feng
Tang, Bei-sha
Tan, Li-ming
Wang, Chun-yu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD).
DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood.
Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells.
Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition.
Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.
American Psychological Association (APA)
Qin, Li-xia& Tan, Jieqiong& Zhang, Hai-nan& Rizwana, Kousar& Lu, Jia-Hong& Tang, Jian-guang…[et al.]. 2017. BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194884
Modern Language Association (MLA)
Qin, Li-xia…[et al.]. BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1194884
American Medical Association (AMA)
Qin, Li-xia& Tan, Jieqiong& Zhang, Hai-nan& Rizwana, Kousar& Lu, Jia-Hong& Tang, Jian-guang…[et al.]. BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194884