![](/images/graphics-bg.png)
Artificial Membrane Induced by Novel Biodegradable Nanofibers in the Masquelet Procedure for Treatment of Segmental Bone Defects
Joint Authors
Wu, Ren-Chin
Yu, Yi-Hsun
Liu, Shih-Jung
Lee, Demei
Chen, Che-Kang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The Masquelet induced-membrane technique for the treatment of segmental bone defects includes a two-stage surgical procedure, and polymethylmethacrylate (PMMA) plays a major role in the treatment.
However, the PMMA spacer must be surgically removed.
Here, we investigated the potential of poly(lactic-co-glycolic acid) (PLGA) nanofibers, a biodegradable material to replace the PMMA spacer, allowing the bioactive membrane to be induced and the spacer to degrade without the additional surgery on a rabbit femoral segmental bone defect model.
PLGA nanofibers were shown to degrade completely six weeks after implantation in the investigated animals, and a thick membrane was found to circumferentially fold around the segmental bone defects.
Results from image studies demonstrated that, in the group without the bone graft, all studied femurs exhibited either nonunion or considerable malunion.
In contrast, the femurs in the bone graft group had a high union rate without considerable deformities.
Histological examinations suggested that the membranous tissue in this group was rich in small blood vessels and the expression of BMP2 and VEGF increased.
Our results demonstrate that the biodegradable PLGA nanofibers may be useful for replacing the PMMA spacer as the bioactive-membrane inducer, facilitating the process of healing and removing the need for repeated surgeries.
American Psychological Association (APA)
Yu, Yi-Hsun& Wu, Ren-Chin& Lee, Demei& Chen, Che-Kang& Liu, Shih-Jung. 2018. Artificial Membrane Induced by Novel Biodegradable Nanofibers in the Masquelet Procedure for Treatment of Segmental Bone Defects. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1194888
Modern Language Association (MLA)
Yu, Yi-Hsun…[et al.]. Artificial Membrane Induced by Novel Biodegradable Nanofibers in the Masquelet Procedure for Treatment of Segmental Bone Defects. Journal of Nanomaterials No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1194888
American Medical Association (AMA)
Yu, Yi-Hsun& Wu, Ren-Chin& Lee, Demei& Chen, Che-Kang& Liu, Shih-Jung. Artificial Membrane Induced by Novel Biodegradable Nanofibers in the Masquelet Procedure for Treatment of Segmental Bone Defects. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1194888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194888