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Acute Exposure to Cigarette Smoking Followed by Myocardial Infarction Aggravates Renal Damage in an In Vivo Mouse Model
Joint Authors
Zeidan, A.
Zouein, Fouad A.
Kaplan, Abdullah
Abidi, Emna
Ghali, Rana
Kobeissy, Firas
Shaito, Abdullah
Baki, Lama
Hayek, Hassan
Dagher-Hamalian, Carole
Nehme, Ali
Husari, Ahmad
Zibara, Kazem
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure.
In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial infarction (MI) using 4 groups: control (C), smoking (S), MI, and S+MI.
Histological analysis of S+MI group showed alterations in kidney structure including swelling of the proximal convoluted tubules (PCTs), thinning of the epithelial lining, focal loss of the brush border of PCTs, and patchy glomerular retraction.
Molecular analysis revealed that nephrin expression was significantly reduced in the S+MI group, whereas sodium-hydrogen exchanger-1 (NHE-1) was significantly increased, suggesting altered glomerular filtration and kidney functions.
Moreover, S+MI group, but not S alone, showed a significant increase in the expression of connective tissue growth factor (CTGF) and fibrotic proteins fibronectin (FN) and α-smooth muscle actin (SMA), in comparison to controls, in addition to a significant increase in mRNA levels of IL-6 and TNF-α inflammatory markers.
Finally, reactive oxygen species (ROS) production was significantly accentuated in S+MI group concomitant with a significant increase in NOX-4 protein levels.
In conclusion, smoking aggravates murine acute renal damage caused by MI at the structural and molecular levels by exacerbating renal dysfunction.
American Psychological Association (APA)
Kobeissy, Firas& Shaito, Abdullah& Kaplan, Abdullah& Baki, Lama& Hayek, Hassan& Dagher-Hamalian, Carole…[et al.]. 2017. Acute Exposure to Cigarette Smoking Followed by Myocardial Infarction Aggravates Renal Damage in an In Vivo Mouse Model. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194892
Modern Language Association (MLA)
Kobeissy, Firas…[et al.]. Acute Exposure to Cigarette Smoking Followed by Myocardial Infarction Aggravates Renal Damage in an In Vivo Mouse Model. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194892
American Medical Association (AMA)
Kobeissy, Firas& Shaito, Abdullah& Kaplan, Abdullah& Baki, Lama& Hayek, Hassan& Dagher-Hamalian, Carole…[et al.]. Acute Exposure to Cigarette Smoking Followed by Myocardial Infarction Aggravates Renal Damage in an In Vivo Mouse Model. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194892