![](/images/graphics-bg.png)
Distinguishing the Unique Neuropathological Profile of Blast Polytrauma
Joint Authors
Hubbard, W. Brad
Greenberg, Shaylen
Norris, Carly
Eck, Joseph
Lavik, Erin
VandeVord, Pamela
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Traumatic brain injury sustained after blast exposure (blast-induced TBI) has recently been documented as a growing issue for military personnel.
Incidence of injury to organs such as the lungs has decreased, though current epidemiology still causes a great public health burden.
In addition, unprotected civilians sustain primary blast lung injury (PBLI) at alarming rates.
Often, mild-to-moderate cases of PBLI are survivable with medical intervention, which creates a growing population of survivors of blast-induced polytrauma (BPT) with symptoms from blast-induced mild TBI (mTBI).
Currently, there is a lack of preclinical models simulating BPT, which is crucial to identifying unique injury mechanisms of BPT and its management.
To meet this need, our group characterized a rodent model of BPT and compared results to a blast-induced mTBI model.
Open field (OF) performance trials were performed on rodents at 7 days after injury.
Immunohistochemistry was performed to evaluate cellular outcome at day seven following BPT.
Levels of reactive astrocytes (GFAP), apoptosis (cleaved caspase-3 expression), and vascular damage (SMI-71) were significantly elevated in BPT compared to blast-induced mTBI.
Downstream markers of hypoxia (HIF-1α and VEGF) were higher only after BPT.
This study highlights the need for unique therapeutics and prehospital management when handling BPT.
American Psychological Association (APA)
Hubbard, W. Brad& Greenberg, Shaylen& Norris, Carly& Eck, Joseph& Lavik, Erin& VandeVord, Pamela. 2017. Distinguishing the Unique Neuropathological Profile of Blast Polytrauma. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194912
Modern Language Association (MLA)
Hubbard, W. Brad…[et al.]. Distinguishing the Unique Neuropathological Profile of Blast Polytrauma. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1194912
American Medical Association (AMA)
Hubbard, W. Brad& Greenberg, Shaylen& Norris, Carly& Eck, Joseph& Lavik, Erin& VandeVord, Pamela. Distinguishing the Unique Neuropathological Profile of Blast Polytrauma. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194912