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Neuroprotective and Memory-Enhancing Effect of the Combined Extract of Purple Waxy Corn Cob and Pandan in Ovariectomized Rats
Joint Authors
Wattanathorn, Jintanaporn
Lertrat, Kamol
Iamsaard, Sittichai
Jittiwat, Jinatta
Suriharn, Bhalang
Kirisattayakul, Woranan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The neuroprotectant and memory enhancer supplement for menopause is required due to the side effects of hormone replacement therapy.
Since purple waxy corn cob and pandan leaves exert antioxidant and acetylcholinesterase inhibition (AChEI) effects, we hypothesized that the combined extract of both plants (PCP) might provide synergistic effect leading to the improved brain damage and memory impairment in experimental menopause.
To test this hypothesis, female Wistar rats were ovariectomized bilaterally and orally given various doses of the functional drink at doses of 20, 40, and 80 mg/kg for 28 days.
The animals were assessed nonspatial memory using object recognition test every 7 days throughout the study period.
At the end of study, they were assessed with oxidative stress status, AChEI, neuron density, and ERK1/2 signal in the prefrontal cortex (PFC).
Interestingly, all doses of PCP increased object recognition memory and neuron density but decreased oxidative stress status in PFC.
Low dose of PCP also decreased AChE activity while medium dose of PCP increased phosphorylation of ERK1/2 in PFC.
Therefore, the improved oxidative stress status and cholinergic function together with signal transduction via ERK in PFC might be responsible for the neuroprotective and memory-enhancing effects of PCP.
American Psychological Association (APA)
Kirisattayakul, Woranan& Wattanathorn, Jintanaporn& Iamsaard, Sittichai& Jittiwat, Jinatta& Suriharn, Bhalang& Lertrat, Kamol. 2017. Neuroprotective and Memory-Enhancing Effect of the Combined Extract of Purple Waxy Corn Cob and Pandan in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194915
Modern Language Association (MLA)
Kirisattayakul, Woranan…[et al.]. Neuroprotective and Memory-Enhancing Effect of the Combined Extract of Purple Waxy Corn Cob and Pandan in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194915
American Medical Association (AMA)
Kirisattayakul, Woranan& Wattanathorn, Jintanaporn& Iamsaard, Sittichai& Jittiwat, Jinatta& Suriharn, Bhalang& Lertrat, Kamol. Neuroprotective and Memory-Enhancing Effect of the Combined Extract of Purple Waxy Corn Cob and Pandan in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194915