Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System
Joint Authors
Kohen, Ron
Ben Yehuda Greenwald, Maya
Frušić-Zlotkin, Marina
Soroka, Yoram
Ben Sasson, Shmuel
Bitton, Ronit
Bianco-Peled, Havazelet
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes).
Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and poor absorption, leading to low efficacy in preventing skin pathologies.
These limitations can be overcome by using a nanotechnology-based delivery system.
Here, we elucidated the possibility of using curcumin encapsulated in a microemulsion preserving its unique chemical structure.
We also examined whether curcumin microemulsion would reduce UVB-induced toxicity in skin.
A significant curcumin concentration was found in the human skin dermis following topical application of a curcumin microemulsion.
Moreover, curcumin microemulsion enhanced the reduction of UV-induced cytotoxicity in epidermal cells, paving the way for other incorporated electrophiles in encapsulated form protecting skin against stress-related diseases.
American Psychological Association (APA)
Ben Yehuda Greenwald, Maya& Frušić-Zlotkin, Marina& Soroka, Yoram& Ben Sasson, Shmuel& Bitton, Ronit& Bianco-Peled, Havazelet…[et al.]. 2017. Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1194921
Modern Language Association (MLA)
Ben Yehuda Greenwald, Maya…[et al.]. Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1194921
American Medical Association (AMA)
Ben Yehuda Greenwald, Maya& Frušić-Zlotkin, Marina& Soroka, Yoram& Ben Sasson, Shmuel& Bitton, Ronit& Bianco-Peled, Havazelet…[et al.]. Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1194921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194921