Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2
Joint Authors
Cai, Lu
Kong, Li-li
Bai, Yang
Tan, Yi
Wang, Yonggang
Xin, Ying
Liu, Feng
Wu, Hao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although angiotensin II (Ang II) was reported to facilitate sperm motility and intratesticular sperm transport, recent findings shed light on the efficacy of Ang II in stimulating inflammatory events in testicular peritubular cells, effect of which may play a role in male infertility.
It is still unknown whether Ang II can induce testicular apoptotic cell death, which may be a more direct action of Ang II in male infertility.
Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid-derived 2)-like 2 (NRF2), the governor of antioxidant-redox signalling.
Eight-week-old male C57BL/6J wild type (WT) and Nrf2 gene knockout mice were treated with Ang II, in the presence or absence of SFN.
In WT mice, SFN activated testicular NRF2 expression and function, along with a marked attenuation in Ang II-induced testicular oxidative stress, inflammation, endoplasmic reticulum stress, and apoptotic cell death.
Deletion of the Nrf2 gene led to a complete abolishment of these efficacies of SFN.
The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.
American Psychological Association (APA)
Wang, Yonggang& Wu, Hao& Xin, Ying& Bai, Yang& Kong, Li-li& Tan, Yi…[et al.]. 2017. Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194954
Modern Language Association (MLA)
Wang, Yonggang…[et al.]. Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194954
American Medical Association (AMA)
Wang, Yonggang& Wu, Hao& Xin, Ying& Bai, Yang& Kong, Li-li& Tan, Yi…[et al.]. Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194954