Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway

Joint Authors

Kim, Eun Hye
Baek, Seungho
Shin, Daiha
Lee, Jaewang
Roh, Jong-Lyel

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-12-31

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

Acquired resistance to cisplatin is the most common reason for the failure of cisplatin chemotherapy.

Hederagenin, triterpenoids extracted from ivy leaves, exhibits antitumor activity in various types of cancer.

However, the therapeutic potential of hederagenin in head and neck cancer (HNC) has remained unclear.

Therefore, we examined the effects of hederagenin in cisplatin-resistant HNC cells and characterized its molecular mechanisms of action in this context.

We evaluated the effects of hederagenin treatment on cell viability, apoptosis, reactive oxygen species (ROS) production, glutathione levels, mitochondrial membrane potential (ΔΨm), and protein and mRNA expression in HNC cells.

The antitumor effect of hederagenin in mouse tumor xenograft models was also analyzed.

Hederagenin selectively induced cell death in both cisplatin-sensitive and cisplatin-resistant HNC cells by promoting changes in ΔΨm and inducing apoptosis.

Hederagenin inhibited the Nrf2-antioxidant response element (ARE) pathway and activated p53 in HNC cells, thereby enhancing ROS production and promoting glutathione depletion.

These effects were reversed by the antioxidant trolox.

Hederagenin activated intrinsic apoptotic pathways via cleaved PARP, cleaved caspase-3, and Bax.

The selective inhibitory effects of hederagenin were confirmed in cisplatin-resistant HNC xenograft models.

These data suggest that hederagenin induces cell death in resistant HNC cells via the Nrf2-ARE antioxidant pathway.

American Psychological Association (APA)

Kim, Eun Hye& Baek, Seungho& Shin, Daiha& Lee, Jaewang& Roh, Jong-Lyel. 2017. Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194983

Modern Language Association (MLA)

Kim, Eun Hye…[et al.]. Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194983

American Medical Association (AMA)

Kim, Eun Hye& Baek, Seungho& Shin, Daiha& Lee, Jaewang& Roh, Jong-Lyel. Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194983

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1194983