ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration
Joint Authors
Liu, Huan
Zhou, Yue
Feng, Chencheng
Huang, Bo
Yang, Minghui
Lan, Minghong
Liu, Chang
Zhang, Yang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Excessive reactive oxygen species (ROS) generation in degenerative intervertebral disc (IVD) indicates the contribution of oxidative stress to IVD degeneration (IDD), giving a novel insight into the pathogenesis of IDD.
ROS are crucial intermediators in the signaling network of disc cells.
They regulate the matrix metabolism, proinflammatory phenotype, apoptosis, autophagy, and senescence of disc cells.
Oxidative stress not only reinforces matrix degradation and inflammation, but also promotes the decrease in the number of viable and functional cells in the microenvironment of IVDs.
Moreover, ROS modify matrix proteins in IVDs to cause oxidative damage of disc extracellular matrix, impairing the mechanical function of IVDs.
Consequently, the progression of IDD is accelerated.
Therefore, a therapeutic strategy targeting oxidative stress would provide a novel perspective for IDD treatment.
Various antioxidants have been proposed as effective drugs for IDD treatment.
Antioxidant supplementation suppresses ROS production in disc cells to promote the matrix synthesis of disc cells and to prevent disc cells from death and senescence in vitro.
However, there is not enough in vivo evidence to support the efficiency of antioxidant supplementation to retard the process of IDD.
Further investigations based on in vivo and clinical studies will be required to develop effective antioxidative therapies for IDD.
American Psychological Association (APA)
Feng, Chencheng& Yang, Minghui& Lan, Minghong& Liu, Chang& Zhang, Yang& Huang, Bo…[et al.]. 2017. ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194988
Modern Language Association (MLA)
Feng, Chencheng…[et al.]. ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194988
American Medical Association (AMA)
Feng, Chencheng& Yang, Minghui& Lan, Minghong& Liu, Chang& Zhang, Yang& Huang, Bo…[et al.]. ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194988