Total Oxidant and Antioxidant Status in Prepubertal Children with Obesity
Joint Authors
Chełchowska, Magdalena
Ambroszkiewicz, Jadwiga
Rowicka, Grażyna
Dyląg, Hanna
Riahi, Agnieszka
Weker, Halina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aims.
Obesity is accompanied by the formation of oxygen free radicals, whose intensified activity without effective defense mechanisms can lead to oxidative stress and related complications.
We evaluated the presence of oxidative stress in obese prepubertal children.
Methods.
The study included 83 healthy children aged 2–10 years (62 with obesity and 21 nonobese controls).
Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidized low-density lipoprotein (ox-LDL), lipid parameters, glucose, and C-reactive protein (CRP) were measured in serum.
Oxidative stress index (OSI) was calculated.
Results.
Serum TOC concentration was significantly higher (p<0.05) and TAC concentration was lower (p<0.05) in obese children.
OSI was higher (p<0.01) in obese subjects compared with controls.
CRP levels were normal in all children, but median CRP value was higher (p<0.01) and HDL cholesterol levels were lower (p<0.05) in the obese group.
We found a significant negative correlation between TAC and ox-LDL concentrations (r=−0.27, p<0.05) in obese children.
Furthermore, obesity duration was positively correlated with TOC level (r=0.32, p<0.05) in this group.
Conclusions.
Obesity-related oxidative stress already occurs in prepubescence.
Early obesity diagnosis and the necessary therapeutic activity implementation is a vital strategy for the prophylaxis of free radical damage and related multiorgan complications.
American Psychological Association (APA)
Rowicka, Grażyna& Dyląg, Hanna& Ambroszkiewicz, Jadwiga& Riahi, Agnieszka& Weker, Halina& Chełchowska, Magdalena. 2017. Total Oxidant and Antioxidant Status in Prepubertal Children with Obesity. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1194994
Modern Language Association (MLA)
Rowicka, Grażyna…[et al.]. Total Oxidant and Antioxidant Status in Prepubertal Children with Obesity. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1194994
American Medical Association (AMA)
Rowicka, Grażyna& Dyląg, Hanna& Ambroszkiewicz, Jadwiga& Riahi, Agnieszka& Weker, Halina& Chełchowska, Magdalena. Total Oxidant and Antioxidant Status in Prepubertal Children with Obesity. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1194994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194994