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Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells
Joint Authors
Załuski, Daniel
Kocki, Janusz
Feldo, Marcin
Bogucka-Kocka, Anna
Kubrak, Tomasz
Bogucki, Jacek
Galkowski, Dariusz
Kaczmarczyk, Robert
Cioch, Maria
Komsta, Łukasz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The presence of multidrug resistance (MDR) in tumor cells is considered as the major cause of failure of cancer chemotherapy.
The mechanism responsible for the phenomenon of multidrug resistance is explained, among others, as overexpression of membrane transporters primarily from the ABC family which actively remove cytostatics from the tumor cell.
The effect of 20 coumarin derivatives on the cytotoxicity and expression of MDR1, MRP1, BCRP, and LRP genes (encoding proteins responsible for multidrug resistance) in cancer cells was analyzed in the study.
The aim of this research included determination of IC10 and IC50 values of selected coumarin derivatives in the presence and absence of mitoxantrone in leukemia cells and analysis of changes in the expression of genes involved in multidrug resistance: MDR1, MRP, LRP, and BCRP after 24-hour exposure of the investigated cell lines to selected coumarins in the presence and absence of mitoxantrone in IC10 and IC50 concentrations.
The designed research was conducted on 5 cell lines derived from the human hematopoietic system: CCRF/CEM, CEM/C1, HL-60, HL-60/MX1, and HL-60/MX2.
Cell lines CEM/C1, HL-60/MX1, and HL-60/MX2 exhibit a multidrug resistance phenotype.
American Psychological Association (APA)
Kubrak, Tomasz& Bogucka-Kocka, Anna& Komsta, Łukasz& Załuski, Daniel& Bogucki, Jacek& Galkowski, Dariusz…[et al.]. 2017. Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195003
Modern Language Association (MLA)
Kubrak, Tomasz…[et al.]. Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195003
American Medical Association (AMA)
Kubrak, Tomasz& Bogucka-Kocka, Anna& Komsta, Łukasz& Załuski, Daniel& Bogucki, Jacek& Galkowski, Dariusz…[et al.]. Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195003