![](/images/graphics-bg.png)
Oxidative Biochemistry Disbalance and Changes on Proteomic Profile in Salivary Glands of Rats Induced by Chronic Exposure to Methylmercury
Joint Authors
Lima, Rafael Rodrigues
Crespo-López, Maria Elena
de Farias-Junior, Paulo Mecenas Alves
Bittencourt, Leonardo Oliveira
Puty, Bruna
Charone, Senda
Aragão, Walessa Alana Bragança
Silva, Marcia Cristina Freitas
Leite, Aline de Lima
Buzalaf, Marilia Afonso Rabelo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Methylmercury (MeHg) is one of the most toxic mercury species, which can cause many systemic damages, but little is known about its effect in the salivary glands.
This study aimed to analyze the mercury levels, oxidative stress, and proteomic profile in parotid, submandibular, and sublingual salivary glands of rats, after chronic MeHg intoxication.
Two groups of twenty male Wistar rats (90 days of age) were used on the experiment.
MeHg group was intoxicated by intragastric gavage with MeHg at a dose of 0.04 mg/kg/day for 60 days, while the control group received only oil.
After the period of intoxication, the glands were collected for evaluation of total mercury levels, proteomic profile, and oxidative balance by analyzing the antioxidant capacity against peroxyl radicals (ACAP), lipid peroxidation (LPO), and nitrite levels.
Our results have showed that mercury levels were significant in all three glands compared to the respective control.
It also showed lower levels of ACAP, as well as higher LPO and nitrite levels.
The proteomic profile presented impairments on structural components of cytoskeleton, metabolic pathways, and oxidative biochemistry.
Thus, the exposure to MeHg was able to generate oxidative stress that could be associated with changes in the proteomic profile of salivary glands.
American Psychological Association (APA)
Bittencourt, Leonardo Oliveira& Puty, Bruna& Charone, Senda& Aragão, Walessa Alana Bragança& de Farias-Junior, Paulo Mecenas Alves& Silva, Marcia Cristina Freitas…[et al.]. 2017. Oxidative Biochemistry Disbalance and Changes on Proteomic Profile in Salivary Glands of Rats Induced by Chronic Exposure to Methylmercury. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1195005
Modern Language Association (MLA)
Bittencourt, Leonardo Oliveira…[et al.]. Oxidative Biochemistry Disbalance and Changes on Proteomic Profile in Salivary Glands of Rats Induced by Chronic Exposure to Methylmercury. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1195005
American Medical Association (AMA)
Bittencourt, Leonardo Oliveira& Puty, Bruna& Charone, Senda& Aragão, Walessa Alana Bragança& de Farias-Junior, Paulo Mecenas Alves& Silva, Marcia Cristina Freitas…[et al.]. Oxidative Biochemistry Disbalance and Changes on Proteomic Profile in Salivary Glands of Rats Induced by Chronic Exposure to Methylmercury. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1195005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195005