Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines
Joint Authors
Carpentier, Rodolphe
Platel, Anne
Salah, Norhane
Nesslany, Fabrice
Betbeder, Didier
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Vaccination faces limitations, and delivery systems additionally appear to have potential as tools to trigger protective immune responses against diseases.
The nanoparticles studied are cationic maltodextrin-based nanoparticles with an anionic phospholipid core (NPL); they are a promising antigen delivery system, and their efficacy as drug vectors against complex diseases such as toxoplasmosis has already been demonstrated.
Cationic compounds are generally described as toxic; therefore, it is of interest to evaluate the behavior of these NPL in vitro and in vivo.
Here, we studied the in vitro toxicity (cytotoxicity and ROS induction in intestinal and airway epithelial cell lines) and the in vivo tolerability and genotoxicity of these nanoparticles administered by the nasal route to a rodent model.
In vitro, these NPL were not cytotoxic and did not induce any ROS production.
In vivo, even at very large doses (1000 times the expected human dose), no adverse effect and no genotoxicity were observed in lungs, stomach, colon, or liver.
This study shows that these NPL can be safely used.
American Psychological Association (APA)
Carpentier, Rodolphe& Platel, Anne& Salah, Norhane& Nesslany, Fabrice& Betbeder, Didier. 2018. Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1195007
Modern Language Association (MLA)
Carpentier, Rodolphe…[et al.]. Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines. Journal of Nanomaterials No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1195007
American Medical Association (AMA)
Carpentier, Rodolphe& Platel, Anne& Salah, Norhane& Nesslany, Fabrice& Betbeder, Didier. Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1195007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195007