H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing
Joint Authors
Hou, Cui-Lan
Wang, Ming-Jie
Zhu, Yi-Chun
Mu, Xue-Pan
Wu, Wei
Sun, Chen
Lv, Qian-Zhou
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aims.
The study was designed to explore whether hydrogen sulphide (H2S) and nitric oxide (NO) generation changed in D-galactose- (D-gal-) induced ageing, the possible effects of exogenous H2S supplementation, and related mechanisms.
Results.
In D-gal-induced senescent mice, both H2S and NO levels in the heart, liver, and kidney tissues were decreased significantly.
A similar trend was observed in D-gal-challenged human umbilical vein endothelial cells (HUVECs).
Sustained H2S donor (NaHS) treatment for 2 months elevated H2S and NO levels in these mice, and during this period, the D-gal-induced senescent phenotype was reversed.
The protective effect of NaHS is associated with a decrease in reactive oxygen species levels and an increase in antioxidants, such as glutathione, and superoxide dismutase and glutathione peroxidase activities.
Increased expression of the H2S-producing enzymes cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS) in the heart, liver, and kidney tissues was observed in the NaHS-treated groups.
NaHS supplementation also significantly postponed D-gal-induced HUVEC senescence.
Conclusions.
Endogenous hydrogen sulphide production in both ageing mice and endothelial cells is insufficient.
Exogenous H2S can partially rescue ageing-related dysfunction by inducing endogenous H2S and NO production and reducing oxidative stress.
Restoring endogenous H2S production may contribute to healthy ageing, and H2S may have antiageing effects.
American Psychological Association (APA)
Wu, Wei& Hou, Cui-Lan& Mu, Xue-Pan& Sun, Chen& Zhu, Yi-Chun& Wang, Ming-Jie…[et al.]. 2017. H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1195023
Modern Language Association (MLA)
Wu, Wei…[et al.]. H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1195023
American Medical Association (AMA)
Wu, Wei& Hou, Cui-Lan& Mu, Xue-Pan& Sun, Chen& Zhu, Yi-Chun& Wang, Ming-Jie…[et al.]. H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1195023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195023