SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mesenchymal stem cells (MSCs) are multipotent cells that are currently being investigated in a wide variety of clinical trials for their anti-inflammatory and immunomodulatory properties as well as their osteogenic and chondrogenic capabilities.
However, there are considerable interdonor variability and heterogeneity of MSC populations, making it challenging to compare different products.
Furthermore, proliferation, differentiation, and immunomodulation of MSCs decrease with aging and ex vivo expansion.
The sirtuins have emerged as a class of protein deacylases involved in aging, oxidative stress, and metabolism.
Sirtuin 3 (SIRT3) is the major mitochondrial deacetylase involved in reducing oxidative stress while preserving oxidative metabolism, and its levels have been shown to decrease with age.
This study investigated the role of SIRT3 in MSC differentiation and aging.
As MSCs were expanded ex vivo, SIRT3 levels decreased.
In addition, SIRT3 depletion reduced MSC differentiation into adipocytes and osteoblasts.
Furthermore, overexpression of SIRT3 in later-passage MSCs reduced aging-related senescence, reduced oxidative stress, and enhanced their ability to differentiate.
These data suggest that overexpressing SIRT3 might represent a strategy to increase the quality and quantity of MSCs utilized for clinical applications.
American Psychological Association (APA)
Denu, Ryan A.. 2017. SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195080
Modern Language Association (MLA)
Denu, Ryan A.. SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195080
American Medical Association (AMA)
Denu, Ryan A.. SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195080