Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies
Joint Authors
Mantzarlis, Konstantinos
Tsolaki, Vasiliki
Zakynthinos, Epaminondas
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sepsis is one of the most important causes of death in intensive care units.
Despite the fact that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and antioxidants play a key role.
The imbalance of the abovementioned substances in favor of oxidants is called oxidative stress, and it contributes to sepsis process.
The most important consequences are vascular permeability impairment, decreased cardiac performance, and mitochondrial malfunction leading to impaired respiration.
Nitric oxide is perhaps the most important and well-studied oxidant.
Selenium, vitamin C, and 3N-acetylcysteine among others are potential therapies for the restoration of redox balance in sepsis.
Results from recent studies are promising, but there is a need for more human studies in a clinical setting for safety and efficiency evaluation.
American Psychological Association (APA)
Mantzarlis, Konstantinos& Tsolaki, Vasiliki& Zakynthinos, Epaminondas. 2017. Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195105
Modern Language Association (MLA)
Mantzarlis, Konstantinos…[et al.]. Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1195105
American Medical Association (AMA)
Mantzarlis, Konstantinos& Tsolaki, Vasiliki& Zakynthinos, Epaminondas. Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195105