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Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both?
Joint Authors
Molfino, Alessio
Monti, Massimo
Amabile, Maria Ida
Muscaritoli, Maurizio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Prognosis and outcomes of critically ill patients are strictly related with inflammatory status.
Inflammation involves a multitude of interactions between different cell types and chemical mediators.
Omega-3 polyunsaturated fatty acids (PUFAs), mainly represented by eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are able to inhibit different pathways including leukocyte chemotaxis, adhesion molecule expression and interactions, and production of inflammatory cytokines, through the action of specialized proresolving mediators (SPMs).
SPMs from omega-6 fatty acids, such as lipoxins, and from omega-3 fatty acids such as resolvins, protectins, and maresins, act in reducing/resolving the inflammatory process in critical diseases, stimulating the phases of resolution of inflammation.
In this light, the resolution of inflammation is nowadays considered as an active process, instead of a passive process.
In critical illness, SPMs regulate the excessive posttrauma inflammatory response, protecting organs from damage.
This review focuses on the role of omega-3 PUFAs as pharma nutrition agents in acute inflammatory conditions, highlighting their effects as anti-inflammatory or proresolving agents.
American Psychological Association (APA)
Molfino, Alessio& Amabile, Maria Ida& Monti, Massimo& Muscaritoli, Maurizio. 2017. Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both?. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1195115
Modern Language Association (MLA)
Molfino, Alessio…[et al.]. Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both?. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1195115
American Medical Association (AMA)
Molfino, Alessio& Amabile, Maria Ida& Monti, Massimo& Muscaritoli, Maurizio. Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both?. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1195115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195115