Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats
Joint Authors
Mazlan, Musalmah
Hamezah, Hamizah Shahirah
Taridi, Nursiati Mohd
Jing, Yu
Liu, Ping
Zhang, Hu
Wan Ngah, Wan Zurinah
Damanhuri, Hanafi Ahmad
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Accumulating evidence suggests that altered arginine metabolism is involved in the aging and neurodegenerative processes.
This study sought to determine the effects of age and vitamin E supplementation in the form of tocotrienol-rich fraction (TRF) on brain arginine metabolism.
Male Wistar rats at ages of 3 and 21 months were supplemented with TRF orally for 3 months prior to the dissection of tissue from five brain regions.
The tissue concentrations of L-arginine and its nine downstream metabolites were quantified using high-performance liquid chromatography and liquid chromatography tandem mass spectrometry.
We found age-related alterations in L-arginine metabolites in the chemical- and region-specific manners.
Moreover, TRF supplementation reversed age-associated changes in arginine metabolites in the entorhinal cortex and cerebellum.
Multiple regression analysis revealed a number of significant neurochemical-behavioral correlations, indicating the beneficial effects of TRF supplementation on memory and motor function.
American Psychological Association (APA)
Mazlan, Musalmah& Hamezah, Hamizah Shahirah& Taridi, Nursiati Mohd& Jing, Yu& Liu, Ping& Zhang, Hu…[et al.]. 2017. Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195117
Modern Language Association (MLA)
Mazlan, Musalmah…[et al.]. Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195117
American Medical Association (AMA)
Mazlan, Musalmah& Hamezah, Hamizah Shahirah& Taridi, Nursiati Mohd& Jing, Yu& Liu, Ping& Zhang, Hu…[et al.]. Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195117